Fucus vesiculosus L., known as bladderwrack, belongs to the brown seaweeds, which are\nwidely distributed throughout northern Russia, Atlantic shores of Europe, the Baltic Sea, Greenland,\nthe Azores, the Canary Islands, and shores of the Pacific Ocean. Fucoidan is a major fucose-rich\nsulfated polysaccharide found in Fucus (F.) vesiculosus. The pharmacokinetic profiling of active\ncompounds is essential for drug development and approval. The aim of the study was to evaluate the\npharmacokinetics and tissue distribution of fucoidan in rats after a single-dose oral administration.\nFucoidan was isolated from F. vesiculosus. The method of measuring anti-activated factor X (anti-Xa)\nactivity by amidolytic assay was used to analyze the plasma and tissue concentrations of fucoidan.\nThe tissue distribution of fucoidan after intragastric administration to the rats was characterized,\nand it exhibited considerable heterogeneity. Fucoidan preferentially accumulates in the kidneys\n(AUC0ââ?¬â??t = 10.74 Ã?¼gÃ?·h/g; Cmax = 1.23 Ã?¼g/g after 5 h), spleen (AUC0ââ?¬â??t = 6.89 Ã?¼gÃ?·h/g; Cmax = 0.78 Ã?¼g/g\nafter 3 h), and liver (AUC0ââ?¬â??t = 3.26 Ã?¼gÃ?·h/g; Cmax = 0.53 Ã?¼g/g after 2 h) and shows a relatively long\nabsorption time and extended circulation in the blood, with a mean residence time (MRT) = 6.79 h.\nThe outcome of this study provides additional scientific data for traditional use of fucoidan-containing\nplants and offers tangible support for the continued development of new effective pharmaceuticals\nusing fucoidan.
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